British Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation against an hidden munitions depot in Syrian territory employed by the IS group, as stated by the UK's MoD.
The site, identified by reconnaissance, was thought to be storing arms and explosives, the release indicated, and was located in mountains just above the ancient city of Palmyra in central Syria.
"Our aircraft employed Paveway IV guided bombs to hit a number of approach shafts down to the site... preliminary assessments are that the target was engaged successfully," officials stated.
There was no sign of any civilian casualties in the attack on Saturday evening and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were supported by a Voyager aerial refuelling aircraft.
Daesh - referred to as the so-called Islamic State - imposed militant control over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This strike shows the UK's leading role, and resolve to operate in unison with allied nations, to stamp out any revival of Daesh and their harmful and extremist ideologies in the region," Britain's Defence Chief John Healey said.
UK warplanes have conducted overwatch operations over Syria to "forestall any attempted comeback" of the group after its military defeat at the battle of Baghuz in 2019, the ministry said.
"I must thank all the members of British forces participating in this operation for their expertise and their courage," Healey commented. "They were part of numerous UK service members stationed over the festive period. This mission, to eliminate dangerous terrorists who pose a risk to our security, shows how our armed forces are ready to step up, throughout the year, keeping Britain secure within its borders and powerful internationally."
Last December, the American forces executed what it termed a "major assault" targeting Islamic State objectives in the country, following an assault killed two US servicemembers and a local interpreter in Palmyra.
The United Nations estimates IS still boasts roughly 5-7 thousand militants in Syria and Iraq.